洛索洛芬致肌红蛋白升高

Increased myohemoglobin due to loxoprofen

1例79岁女性类风湿性关节炎患者口服洛索洛芬60mg后约2h出现全身乏力、大汗、红色尿。血肌红蛋白938μg/L,尿肌红蛋白2102μg/L,同时伴有血尿及白细胞升高。考虑肌红蛋白升高,为洛索洛芬所致。停用洛索洛芬,并行抗感染及支持治疗。停药第7天血肌红蛋白24μg/L,尿肌红蛋白174μg/L。但泌尿系统感染未改善,继续治疗。

A 79-year-old woman with rheumatoid arthritis was administered loxoprofen 60 mg. Two hours later, she developed generalised weakness, polyhidrosis, and red urine. Her blood myohemoglobin was 938 μg/L and urinary myohemoglobin was 2102 μg/L. Meanwhile the patient developed hematuria and her leukocyte count increased. Increased myohemoglobin was considered to be induced by loxoprofen. Loxoprofen was discontinued and the patient received anti-infective and supportive treatments. On day 7 of drug discontinuation, the blood myohemoglobin was 24 μg/L and urinary myohemoglobin was 174 μg/L. But her infection of urinary system did not improve and therapy was continued.