伊马替尼相关心包积液及心房颤动

Pericardial effusion and atrial fibrillation associated with imatinib

1例68岁胃恶性间质瘤女性患者术后口服伊马替尼400mg,1次/d。半年后超声心动图示心包少量积液,5年后出现双下肢轻度水肿、心房颤动,超声心动图示心包中等量积液。停用伊马替尼,2周后心包积液减少;3周后心包积液完全消失,且未再发作心房颤动,双下肢水肿明显减轻。再次按照原剂量服用伊马替尼,2周后再次出现少量心包积液,3及6个月时超声心动图均未见心包积液,且未再发作心房颤动。

A 68-year-old woman with malignant gastric stromal tumor received imatinib 400 mg once daily after surgery. Half a year later, ultrasonic cardiogram showed a mild pericardial effusion. Five years later, the patient developed mild edema in both lower extremities and atrial fibrillation, and ultrasonic cardiogram showed a moderate pericardial effusion. Imatinib was discontinued and, two weeks later, pericardial effusion decreased. Three weeks later, pericardial effusion subsided completely, atrial fibrillation did not recur, and her lower limbs edema significantly improved. Imatinib was readministered according to the above-mentioned dosage. Two weeks later, a little pericardial effusion appeared and, on months 3 and 6, ultrasonic cardiogram revealed no pericardial effusion and she did not present with atrial fibrillation.