2型糖尿病下肢血管病变患者血尿酸干预治疗的获益研究

The Benefit Study of Interfere Blood Uric Acid for Lower Extremity Vascular Disease in Type 2 Diabetic

目的:探讨2型糖尿病下肢血管病变患者血尿酸干预治疗是否获益。方法:本研究选择2型糖尿病合并高尿酸患者240例,女性108例,男性132例,全部受试者均采用高分辨彩色多普勒超声检查判定下肢动脉病变程度,按下肢血管病变严重程度进行评分,所有入选病例分为2型糖尿病下肢血管正常、轻度病变、中度病变和重度病变,在血糖、血压、血脂控制达标基础上随机分为两组,血尿酸干预组和非干预组,1年后所有患者再次彩超检查,下肢血管病变由正常→轻→中→重任何一种程度改变均记录为病变进展,否则记录为非进展。分析两组患者的下肢血管病变进展情况。结果:本研究结果显示血尿酸干预组较非干预组下肢血管病变进展显著减慢(P<0.05)。结论:血尿酸干预治疗可以使2型糖尿病下肢血管病变患者明显获益。

Objective： To investigate whether patients of Type 2 diabetes and leg vasculopathy can benefit from treaanent of blood uric acid.Methods：Our study choose 240 patients who suffer from type 2 diabetes and hyper-uric acid, among of them, 108 are female, the other 132 are male, we give all of them high-resolution color Doppler ultrasonography to estimate level of leg vasculopathy.To grade by the level of leg vasculopathy. All of them were divided into nonual group, lightly group, middle group and severe group, then each group was divided into two groups based on their blood glucose, pressure and fat reach standards. One is treatment group, the other is non-treatment group. One year later we give all patients high-resolution color Doppler ultrasonography again. When leg vaseulopathy changes from normal to any of lightly, middle or severe ,we think it progresses, otherwise we think it dosen＇t progress. We analyze the progress of two groups. Results：Our study shows that leg vasculopathy of treatment group progresses slower than non-treatment group（P〈0.05）.Conclusions：Type 2 diabetes and leg vasculopathy can benefit from treatment of hlood uric acid.