不同剂量阿托伐他汀对急性冠脉综合征患者血清炎症因子的影响

Effect of Different Doses of Atorvastatin on Serum Inflammation Factors in Acute Coronary Syndrome

目的:观察不同剂量阿托伐他汀强化治疗对急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)及白细胞介素(IL)-6的影响。方法:96例ACS患者随机分为A、B、C三组,A组:给予常规量阿托伐他汀20mg/d,B、C组:给予阿托伐他汀40/80mg/d,用免疫比浊法分别检测治疗前及治疗1月后患者血清hs-CRP及IL-6水平。结果:用药后hs-CRP、IL-6水平B组较A组明显降低(P<0.05),C组又较B组明显降低(P<0.05)。结论:阿托伐他汀能降低ACS患者hs-CRP及IL-6水平,且呈剂量依赖性。

Objective： To investigate the effect of different doses of atorvastatin on serum high sensitivity C-reactive protein （hs-CRP） and interleukin 6（IL-6） in the patients with acute coronary syndrome （ACS）.Methods：96 ACS patients were randomly divided into A, B and C, A group of three groups： to the conventional quantity atorvastatin 20 rag/d, B, C groups： give atorvastatin 40, 80 rag/d, hs-CRP and IL-6 levels were measured before treatment and after 1 month.Results：After treatment,the levels of hs-CRP, and IL-6 were lowered in B group compared with A group （P〈0.05）,while its were lowest in C group （P〈0.05）. Conelusions：Atorvastatin reduced ACS patients hs-CRP and IL-6 level, and a dose dependent.