纳洛酮治疗慢性呼吸衰竭并发肺性脑病48例疗效观察

Clinical Observation of Naloxone in the Treatment of 48 Cases of Chronic Respiratory Failure with Pulmonary Encephalopathy

目的:探讨纳洛酮治疗慢性呼吸衰竭并发肺性脑病的临床疗效。方法:将88例慢性呼吸衰竭并发肺性脑病患者随机分为观察组(48例)和对照组(40例),对照组给予常规综合治疗,观察组在综合治疗基础上加用纳洛酮注射剂,连用3天。比较两组的治疗效果以及治疗前后动脉血气、神经系统症状变化。结果:观察组的总有效率(87.5%)明显高于对照组(62.5%)(P<0.05);观察组的PaO2明显高于对照组(P<0.05),PaCO_2则明显低于对照组(P<0.05);治疗过程中无肝、肾功能损害等不良反应发生。结论:纳洛酮治疗慢性呼吸衰竭并发肺性脑病临床疗效确切、安全。

Objective： To explore the clinical effect of naloxone in treatment of chronic respiratory frailure with pulmonary encephalopathy.Methods：88 cases of chronic respiratory failure with pulmonary encephalopathy were randomly divided into observation group and control group.40 cases in the control group were received general treatment,48 cases in the observation group were given naloxone on the basic of general treatment for 3 days.The clinical effect, arterial blood gas and mind change before and after therapy were compared.Results： After treatment, the total effective rate in the observation group（87.5%） was significantly higher than that in the control group（62.5%）（P〈0.05）. PaO2 in the observation group was significantly higher than that in the control group（P〈0.05）.PaCO2 in the observation group was significantly lower than that in the control group（P〈0.05）.Conelusions：Naloxone is an effective and less side-effect medicine for treatment of chronic respiratory failure with pulmonary encephalopathy.