血清胱抑素C在严重脓毒血症急性肾损伤的临床应用

The Clinical Practice of Cystatin C in the Aspect of Severe Sepsis Acute Kidney Injury

目的:探讨血清胱抑素C(Cys C)在严重脓毒血症急性肾损伤的早期诊断中的价值。方法:应用颗粒增强免疫比浊法测定本院ICU收治的严重脓毒血症急性肾损伤的60例患者的Cys C,并与其血清肌酐、尿素氮进行比较。结果:严重脓毒血症导致急性肾功能不全患者的各参数与健康体检者比较,t=2.137,P<0.05,肾功能衰竭、尿毒症患者与健康体检者比较,t=2.645,2.653,P<0.01;肾功能不全与肾功能衰竭患者的Cys C异常率均显著高于另外两种测定方法,x^2=3.92,4.07,P<0.05提示两组比较差异显著,有统计学意义。结论:CysC在严重脓毒血症中早期诊断急性肾损伤具有更理想的敏感度和特异度。

Objective： The objective of this essay focused on exploring the value of Cystatin C in the aspect of severe sepsis acute kidney injury in early diagnosis.Methods：Application of granule to strengthen ITM Immunoturbidimetry to estimate the Cystatin C of 60 patients with severe sepsis acute kidney injury that our hospital have accepted in the department of ICU. And at the same time, compared their Serum Creatinine and urea nitrogen. Results：We have gained the following results： every parameter of severe sepsis cause acute renal insufficiency patients compared with that of the healthy person, t=2.137P〈0.05, patients of kidney failure and uremia compared with the healthy person, t=2.645,2.653,P〈0.01;the Cystatin C＇ abnormal rate of patients of Renal insufficiency and kidney failure were higher than those of the other two estimation methods, x^2=3.92,4.07, P〈0.05 suggested that two groups of comparative difference were evident, and embodied the useful meaning of statistics. Conclusions： Cystatin C in the aspect of severe sepsis acute kidney injury entailed idealer sensitivity and specificity.