摘要
DREAM/calsenilin/KChIP3 is a calcium binding protein of the neuronal calcium sensor superfamily.DREAM interacts with DRE(downstream regulatory element) sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular compartments.Work from different laboratories has identified a growing list of interacting proteins that constitutes the DREAM interactome.The knowledge of these interactions has greatly contributed to the understanding of the various physiological functions of DREAM.
DREAM/calsenilin/KChIP3 is a calcium binding protein of the neuronal calcium sensor superfamily.DREAM interacts with DRE（downstream regulatory element） sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular compartments.Work from different laboratories has identified a growing list of interacting proteins that constitutes the DREAM interactome.The knowledge of these interactions has greatly contributed to the understanding of the various physiological functions of DREAM.
基金
supported by grants from Ministerio Ciencia e Innovacion (Grant Nos.SAF2007-62449 to José R.Naranjo,SAF2005-04682 and SAF2008-03469 to Britt Mellstrom)
CIBERNED to Britt Mellstrom and José R.Naranjo and from Comunidad Autonoma de Madrid,Fundación La Caixa(Grant No.BM04-167-0)
the EU 6th Framework Program (NeuroNE)to José R.Naranjo
