摘要
目的探讨CD146蛋白在胰腺癌中的表达及其临床意义。方法选取60例胰腺癌组织和10例正常胰腺组织用免疫组织化学法检测其中CD146蛋白的表达,分析其与临床病理学特征的关系。结果 CD146蛋白在胰腺癌组织中的阳性表达率为83.33%,显著高于其在正常胰腺组织中的表达30.00%(P<0.01)。胰腺癌组织中CD146蛋白的高表达与肿瘤大小、淋巴结转移和临床分期有关(P<0.01)。结论 CD146蛋白与胰腺癌的恶性发展和转移有关。
Objective To explore the expression and its clinical sighificance of CD146 protein in pancreatic cancer. Methods Sixty cases of pancreatic cancer tissue and 10 cases of normal pancreas tissue and immunohistochemistry methods were used test which CD146 protein expression, and analyzing the clinicopathologieal features of the relationship. Results CD146 protein in pancreatic cancer tissue of positive expression rate was 83.33%, significantly higher than the normal pancreatic tissue in the expression of 30.00% with a significant difference （P〈0.01 ）. Pancreatic cancer in the high CD146 organization protein expression and tumor size, lymph node metastasis and the clinical stages have significant correlation （P 〈0.01 ）. Conclusion CD146 protein and pancreatic cancer development and transfer the malignant.
出处
《中国现代医生》
2011年第20期142-143,共2页
China Modern Doctor
