喀什地区维族妇女乳腺癌转移复发风险初步探讨

Kashgar Uighurs risk of metastasis and recurrence of breast cancer in womendiscussed

目的:探讨新疆喀什地区维吾尔族妇女乳腺癌复发转移风险,为临床术后的综合治疗方案和预后评估提供可靠的依据。方法:收集本院2009～2010年行手术切除的维吾尔族妇女乳腺癌患者72例,采用免疫组化En-Vision法检测乳腺癌组织中ER、PR、HER2、CK5/6、Ki-67、E-cad,做出6项复发转移风险评估的基因表达谱分类。结果:72例患者中40岁以上年龄患者56例,占77.78%;浸润性导管癌64例,占88.89%,Ⅱ～Ⅲ级以上高级别者占78%;肿瘤大小:T2以上者61例,占85%;查到脉管浸润65例,占90.3%;有淋巴结转移者52例,占72%;激素受体阳性49例,占76.6%,HER2阳性3+患者13例,占20.3%(13/64)。结论:喀什地区维族妇女乳腺癌有较高的复发风险,激素受体阳性占77.6%,提示本地维族妇女乳腺癌大部分适用于内分泌治疗。

Objective：kashi region of xinjiang Uighur women for the transfer of risk,breast cancer recurrence of clinical postoperative comprehensive treatment scheme and provide reliable basis for prognostic evaluation. Methods：to collect our 2010 in 2009 from line of uighurs women surgical excision 72 patients with breast cancer patients.By using immunohistochemistry EnVision method（EnVision kit） detection breast cancer tissues,ER、PR、HER2、CK5/6、Ki-67,E-cad,make six relapse and metastasis risk assessment the gene expression profiles of classification. Results：72 patients with forty years age 56 cases 77.78%,accounted for;infiltrating ductal carcinoma,accounted for 64 cases 88.89%;Ⅱ-Ⅲ class above the high level,accounts for about 78%;tumor size T2 61 cases is occupied 85% above;to check,65 patients with vascular invasion of text.The electors have lymph node metastasis 52 cases,72 per cent.6 hormone receptor-positive 76.6% 49 cases of patients,HER2 positive 3＋13 cases accounted for 20.3%（13/64）. Conclusion：region have higher Uighur women breast cancer risk of a recurrence;Hormone receptor-positive 77.6%,hints of local Uighur women most suitable for endocrine therapy of breast cancer.