二甲双胍对IGT的干预治疗疗效观察

Observation of the Effect of Metformin Intervention Therapy for IGT

近年来糖尿病（ＤＭ）和糖耐量减低（ＩＧＴ）患病率有逐年增高的趋势，研究发现几乎所有的ＤＭ患者在发生ＤＭ之前，均经过ＩＧＴ阶段。本文通过对３２例ＩＧＴ者随机分为二甲双胍治疗组及非药物干预治疗组比较分析，结果提示，二甲双胍治疗组比非药物干预治疗组ＤＭ发生率明显减少，而ＩＧＴ向糖耐量正常（ＮＧＴ）人转化者则明显增多，这可能是二甲双胍具有不刺激胰岛β细胞分泌胰岛素，且能预防和减轻胰岛素抵抗，减轻高胰岛素血症之特点，进而能针对ＩＧＴ的基本缺陷——胰岛素抵抗和胰岛素分泌异常进行干预治疗，结果可纠正ＩＧＴ患者的糖代谢紊乱，防止ＩＧＴ向ＤＭ转化，同时又能使ＩＧＴ向糖耐量正常（ＮＧＴ）人转化。因此，用二甲双胍对ＩＧＴ的干预治疗对提高ＩＧＴ人群的生活质量，减少ＤＭ的发病率具有重要的意义。

In recent years the morbidity of diabetic mellitus(DM) and impaired glucose tolerance(IGT) were tending upwards year after year.Studies found that almost all the diabetes mellitus patients experienced the IGT stage before DM occurred.In order to investigate the effect of metformin(DMBG) intervention therapy for IGT,32 patients with IGT were randomly divided into two groups,treated with DMBG(group B) and treated with nondrugs(group A).The results showed that diabetic morbidity in group B reduced obviously more than that in group A,and the number of patients transforming into normal went up significantly.The reason may be that DMBG has the character of not stimulating cell to release insulin as well as preventing and decreasing insulin resistance and remitting hyperinsulinemia. Therefore,DMBG intervention therapy for the basic deficiencies of IGT which are insulin resistance and abnormal insulin secretion could correct the glucose metabolism disturbance,prevent IGT from transforming into DM,change IGT into normal.These results suggested that interventional treatment with metformin for IGT means a great deal to those IGT patients in improving quality of life and reducing DM incidence.