中晚期宫颈癌介入栓塞化疗的综合疗效观察

The observation on comprehensive therapeutic effect of interventional embolization chemotherapy in advanced cervical cancer

目的探讨介入栓塞化疗在中晚期宫颈癌治疗中的疗效。方法136例中晚期宫颈癌患者随机分为对照组（放疗组）68例和观察组（介入栓塞化疗组）68例，将两组患者的总有效率、不良反应发生率、二期手术率及治疗前后的血清癌胚抗原（CA125）、鳞状细胞癌抗原（SCC）、细胞角质素19（CY211）水平进行统计及比较。结果观察组的治疗总有效率（83．8％比66．2％）及二期手术率（89．7％比48．5％）均高于对照组，不良反应发生率低于对照组（63．2％比73．5％），血清CA125[（37．89±16．78）比（52．36±16．98）U／m1]、SCC[（0．68±0.42）比（1．52±0．36）μg／L]及CY211[（4．86±2．21）比（8．45±2．85）ng／L]水平低于对照组（P〈0．05或P〈0．01）。结论介入栓塞化疗在中晚期宫颈癌中的综合疗效较佳，为中晚期宫颈癌的有效治疗方法之一。

Objective To study the comprehensive therapeutic effect of interventional embolization chemotherapy in advanced cervical cancer. Methods 136 patients, with advanced cervical cancer were selected as research object, and they were randomly divided into control group（ radiotherapy group） 68 cases and observation group（ inter- ventional embolization chemotherapy group） 68 cases,then the total effective rate,incidence of adverse reactions, see- ondary operation rate and serum CA125 ,SCC and CY211 of two groups before and after the treatment were analyzed and compared. Results The total effective rate（ 83.8% vs 66.2% ） and secondary operation rate（ 89.7% vs 48.5% ） of observation group was higher than that of control group,incidence of adverse reactions（ 63.2% vs73.5% ） was lower than that of control group, serum CA125 [ （ 37.89 ± 16. 78 ） vs （ 52.36 ± 16.98 ） U/ml ], SCC [ （ 0. 68 ± 0.42） vs （ 1.52 ± 0.36 ） μg/L] and CY211 [ （4.86 ± 2.21 ） vs （ 8.45 ± 2.85 ） ng/L ] were all lower than those of control group. （ P 〈 0.05 or P 〈 0.01 ） ,there were significant differences. Conclusion The comprehensive therapeutic effeet of interventional embolization chemotherapy in advanced cervical cancer was better, and it was one of effective methods in advanced cervical cancer.