无创正压通气治疗慢性心力衰竭疗效观察

Clinical curative effect of chronic heart failure treated by noninvasive positive pressure ventilation method

目的观察无创正压通气（NPPV）治疗慢性心力衰竭（CHF）的临床疗效。方法48例CHF患者进行随机分为吸氧下常规药物治疗组（对照组）24例和NPPV下常规药物治疗组（观察组）24例。观察两组治疗前后血浆N端脑钠肽前体（proN-BNP）和心功能的变化。结果观察组总有效率92％，明显高于对照组的66％（x2=3．7851，P〈0．05）；两组治疗后血浆proN—BNP、呼吸次数、心率均低于治疗前（t=2．787、2．815、2．856、2．789、2．804、2．840，均P〈0．01）；观察组治疗后血浆proN—BNP、心率均低于对照组（t=2．123、2．221，均P〈0．05）。结论NPPV能显著改善心功能、降低血浆proN-BNP水平，显著提高患者的治疗效果。

Objective To observe the clinical curative effect of chronic heart failure（CHF） treated by noninvasive positive pressure ventilation （NPPV）. Methods 48 cases of CHF were randomly assigned to conventional drug treatment under oxygen （control group, n = 24 ）and non-invasive positive pressure ventilation （NPPV）under the conventional therapy group （observation group, n = 24）. The plasma N-brain natriuretic peptide（proN-BNP） and cardiac function changes in two groups before and after treatment were observed. Results The total effective rate 92% in observation group was significantly higher than 66% in control group （ x2 = 3. 7851, P 〈 0.05 ） ; The plasma proN- BNP,respiratory rate and heart rate after treatment in two groups were lower than before treatment（ t = 2.787,2.815, 2. 856,2. 789,2. 804,2. 840 ,all P 〈0.01 ） ;The plasma proN-BNPand heart rate in observation group after treatment were lower than the control group （ t = 2.193,2.221, all P 〈 0. 05 ）. Conclusion Noninvasive positive pressure ventilation could significantly improve heart function, reduce plasma proN-BNP and enharce curative effect.