阿托伐他汀对原发性高血压合并高脂血症患者的心率变异性的影响

Effects of atorvastatin on heart rate variability in hypertensive patients with hyperlipidemia

目的探讨原发性高血压合并高脂血症患者的心率变异性(HRV)特点及阿托伐他汀对其影响。方法 50例原发性高血压合并高脂血症患者,口服阿托伐他汀(10 mg/d)8周,观察治疗前后HRV变化并与正常对照组(40例)比较。结果原发性高血压合并高脂血症患者的HRV时域参数(SDNN、SDANN、SDNN Index)治疗前明显低于正常组,给予阿托伐他汀8周干预治疗后HRV指标明显上升。低频功率与高频功率比值(LF/HF)显著降低(P<0.01)。结论原发性高血压合并高脂血症患者自主神经活动明显受损,其迷走神经张力降低,交感神经张力相对增高,发生心源性猝死的危险性明显增加。阿托伐他汀能有效地提高心脏迷走神经张力,降低交感神经张力,有可能减少心律失常性死亡。

Objective To investigate the effect of atorvastatin on heart rate variability（HRV） in patients with essential hypertension（EH） and hyperlipidemia.Methods 50 patients with EH and hyperlipidemia took atorvastatin（10 mg/d） orally for eight weeks.The change of HRV was analyzed and compared with that of 40 healthy controls.Results The HRV（SDNN,SDANN,SDNN index） of patients with EH and hyperlipidemia was lower than that of healthy controls.After atorvastatin treatment,SDNN,SDNN index and HF increased but LF/HF decreased markedly（P0.01）.Conclusion Atorvastatin can increase cardiac vagal activity and decrease sympathetic activity in patients with EH and hyperlipidemia,which suggests that atorvastatin may reduce the arrhythmic mortality.