摘要
设计了以羟基甲叉基丙二酸二乙酯钠盐为原料合成３氯４氟苯胺基甲叉基丙二酸二乙酯的方法，收率为５１７％．
Chloro4fluorophenyl)aminomethylenemalonic acid diethyl ester is the key intermediate for the synthesis of the antibacterial drug norfloxacin.A novel synthetic method starting from hydroxylmethylene malonic acid diethyl ester was designed and the overall yield was 517%.
出处
《沈阳药科大学学报》
CAS
CSCD
1999年第3期179-181,211,共4页
Journal of Shenyang Pharmaceutical University
关键词
氟哌酸
中间体
合成
抗菌素
喹诺酮类
chloro4fluorophenyl)aminomethylenemalonic acid diethyl ester
hydroxymethylenemalonic acid diethyl ester
norfloxacin
intermediate
synthesis
