热分析方法在药物制剂学中的应用

Application of the Thermal Analysis Method to Pharmaceutics

简述了近年来热分析方法在药物制剂研究中的应用．ａ．非晶态药物在制剂制备过程中晶型转化的研究．ｂ．贮存条件对药物晶型转化的影响．ｃ．含有丙二醇的软膏中药物与β－环湖精衍生物形成的包合物的鉴别．ｄ．控释片中主药的固体分散物的研究．ｅ．赋形剂、湿度对药物的片剂稳定性影响的研究．ｆ．透皮吸收制剂研究中皮肤状态的鉴别．结论：热分析方法在药物制剂研究中的应用是多方面的，因此具有较为广泛的应用价值．

The termal Analysis method has many virtues of operating morosely:the quantity of the needed sample was very small and the reproductivity of this method was satisfactory,therefore it is used in the chemical industry,the mineral products,the metallurigical industry,the food products and medicincs,et al.The paper concisely introduces the application of the thermal analysis method to pharmaceutics in recent years.a.The study on the change from the amorphous form to the crystal morphology of a medicine in the pharmaceutical process.b.The effect of storage conditions on the change of crystal morphology.c.The distinction of the inclusion compound of a medicine with cyD and its derivation in the ointment containing propylene glycol.d.The study on solid dispersion of medicine in the controlledreleased tablet.e.The study on stabilization of tablets in the presence of excipients and in the presence of moisture.f.The distinction of the skin state for investigation of perculaneous absorption dosage.