徐州市559株结核分枝杆菌耐药性分析

Analysis of 559 mycobacterium tuberculosis resistant to anti-tuberculosis drug in Xuzhou

目的:研究徐州市肺结核病人耐药情况。方法:用改良酸性罗氏培养基对徐州市559例肺结核病人进行痰培养,再对菌株进行菌型鉴定和药物敏感性试验。结果:对4种药物都敏感的占62.79%。对1种或1种以上药物耐药的占37.21%。对1种药的耐药率分别为:H-28.09%(157/559),S-26.83%(150/559),R-21.82%(122/559),E-12.34%(69/559)。我市肺结核病人总体耐多药率为16.63%,其中初治患者耐多药率为2.08%,复治患者耐多药率为32.10%。结论:我市结核病人耐药率仍处于较高水平,一线药对肺结核病人没有良好治疗效果,初治病人和复治病人耐药率差别有显著性。

Objective：To study the status of anti-tuberculosis drug resistance in patients with pulmonary tuberculosis in Xuzhou.Methods： The reformed L-J medium was applied to 559 patients with TB to perform sputum culture.The bacterial type was evaluated and drug susceptibility testing was performed.Results： The susceptible rate to four drugs is 62.79%.The resistance to one or more drugs is 37.21%.The resistant rate to one drug are： H-28.09%（157/559）,S-26.83%（150/559）,R-21.82%（122/559）,E-12.34%（69/559）.The overall multi-drug resistant rate in our city is 16.63%,and the rate in the primary and re-treated case is 2.08% and 32.10% respectively.Conclusion： The drug resistant rate in our city is still very high.The first-line drugs do not have good result in patients with pulmonary tuberculosis.There is a significant difference between the drug-resistant rate in the primary and re-treated cases.