北京市成年人群甲型肝炎病毒血清抗体流行率调查

A seroprevalence of anti-HAV IgG in the adults of Beijing city

目的:了解北京市成年人群甲型肝炎(简称甲肝)抗体流行率。方法:调查北京市20岁以上常住居民548人,采用微粒子酶免疫分析法(MEIA)检测血清甲型肝炎病毒抗体(抗-HAV IgG)。结果:北京市成人抗-HAV IgG阳性率为58.58%(321/548);男性阳性率为51.34%(134/261);女性阳性率为65.15%(187/287);20岁～29岁年龄组阳性率为53.33%(128/240);30岁～39岁年龄组阳性率为58%(116/200);40岁～49岁年龄组阳性率为71.3%(77/108)。北京市成人抗-HAV IgG中位数为117.44,男性抗-HAV IgG中位数为27.84,女性抗-HAV IgG中位数为281.62,20岁～29岁年龄组抗-HAV IgG中位数为28.74,30岁～39岁和40岁～49岁两个年龄组抗-HAV IgG中位数均大于1000000。结论:北京市20～39岁年龄组人群抗-HAV IgG阳性率处于较低水平,不能形成有效免疫屏障,应注意防范这部分人群发生甲肝流行的风险。

Objective：To investigate the seroprevalence of anti-HAV IgG in adults of Beijing.Methods：Serum samples were collected from 548 subjects of local residents aged 20～88 years old.The anti-HAV IgG in sera was detected with a micro-particle enzyme immunoassay（MEIA）.Results：The overall seroprevalence rate of anti-HAV IgG in adults was 58.58%（321/548）.The positive rate of the male was 51.34%（134/261）,while the positive rate of the female was 65.15%（187/287）.The positive rate of anti-HAV IgG in the adults aged 20～29 years,30～39 years,40～49 years,were 53.33%（128/240）,58%（116/200）,and 71.3%（77/108） respectively.Median of anti-HAV IgG in adults of Beijing was 117.44,median of anti-HAV IgG of the male was 27.84,median of anti-HAV IgG of the female was 281.62.Median of anti-HAV IgG in adults aged 20～29 was 28.74,while Median of anti-HAV IgG of in adults aged 30～39 and 40～49 were more than 1000000.Conclusion： The positive rate of anti-HAV IgG in the adults aged 20～39 years was at relatively lower level,which did not form effective immunity barrier,therefore,risk of the HAV prevalence should be taken more care.