妊娠期血常规部分参数及凝血功能的改变与低出生体重的关系

The relation of low birth weight and the changes of the part parameters of blood routine test and coagulation test in pregnancy.

目的探讨高浓度血红蛋白是否与胎儿生长受限有相关性,是否与血栓前状态存在一定的关系。方法回顾性分析足月正常妊娠孕妇298例和分娩足月低体重儿的孕妇104例,分别在妊娠早中晚期进行血液学指标检查:HGB、HCT、PLT,妊娠晚期检查:PT、INR、FIB、A;;PTT、TT。结果足月低体重儿组与正常妊娠组比较:早期的HCT、中期与晚期的HGB和HCT均有升高,PT、INR、A;;PTT均有下降,差异有显著性意义(P<0.05)。结论在妊娠中晚期出现的高浓度血红蛋白和妊娠期出现的红细胞压积增高可能导致异常的血液高凝状态,从而影响胎儿的生长发育。

Objective: To investigate whether high maternal hemoglobin concentrations is associated with fetal growth restriction,whether a certain relationship exists between the high hemoglobin concentration and prothrombotic state.Methods: A retrospective analysis of 298 cases of full-term normal pregnant women and 104 cases of low birth weight full-term pregnant women were conducted in the three trimesters of pregnancy for Hematology Indicators examination: HGB,HCT,PLT,the third trimester's examination: PT,INR,FIB,APTT,TT.Results: Early gestation's HCT,and HGB and HCT in medium-term and late term in patients with term low birth weight were significantly higher than these in normal pregnancy(P<0.05).PT,INR,APTT were significantly lower than these in normal pregnancy(P<0.05).Conclusion: High hematocrit in pregnancy and the high hemoglobin concentration in the second and the third trimesters of pregnancy may lead to abnormal hypercoagulable states,thus affecting fetal growth.