口服万艾可对宫腔内人工授精妊娠结局的影响

The effect of administration of sildenafil citrate on intrauterine insemination.

目的通过总结106例162周期宫腔内人工授精(IUI)结局,分析手术当日口服万艾可对IUI妊娠率的影响。方法选择男方因素行IUI夫妇共106对,男方因素全部为弱精子症,随机分常规组和万艾可组,常规组按照常规IUI方式进行,万艾可组在男方取精前30-60min口服万艾可50mg,比较两组精液量,精液上游前后活动精子总数,妊娠率。结果万艾可组精液量(2.96±1.18)ml高于常规组(2.02±0.25)ml(P<0.05),且万艾可组处理后活动精子总数(19.96±6.68)×106高于常规组(10.56±3.68)×106(P<0.05)。在妊娠率方面,万艾可组与常规组分别为妊娠率19.7%与8.9%(P<0.05)。结论口服万艾可可以即时提高精子活动力,增加人工授精有效的精子数量;处理后精子总数是影响妊娠率的重要因素。

Objective： To investigate the effect of administrating sildenafil citrate on pregnancy rate of intrauterine insemination by means of analyzing patients of IUI cycles.Methods：Infertility couples were divided into two groups.In group one,the male parters administrated 50mg sildenafil citrate 30-60 minites early before collecting semen.In group two,male parters collected semen routinely.Comparisons of semen volumes,total motility sperm（TMS） and post-swim up total motility sperm（PTMS） quantility and pregnancy rates.Results：In group one,male semen volumes,PTMS quantility were significantly higher than those of group two（2.02±0.25ml VS.2.96±1.18 ml）（10.56±3.68）×106 VS.（19.96±6.68） ×106.There were statistical differences in the pregnancy rate between two groups（8.9% VS.19.7%）.Conclusions： Sildenafil citrate can improve asthenozoospermic male semen volumes and PTMS in intrauterine insemination cycles.PTMS is key factor to increase pregnancy rate.