摘要
目的探讨经阴道小卵泡穿刺抽吸对多囊卵巢综合征（PCOS）不孕患者卵巢窦卵泡计数及妊娠的影响。方法将80例行人绝经期促性腺激素（hMG）促排卵的PCOS患者随机分为二组,观察组40例,于卵泡直径达8~10mm时行经阴道小卵泡穿刺;对照组40例,仅行常规促排卵,连续观察6个月,观察穿刺治疗前后性激素FSH、LH、T水平的变化,比较二组患者卵巢窦卵泡计数及妊娠情况。结果观察组与治疗前比较,21例患者的血清LH/FSH、T降低,其中5例血清LH/FSH、T恢复正常,穿刺前后LH/FSH、T有统计学差异（P〈0.01）,对照组变化不明显,观察组40例患者卵巢基础窦卵泡计数降至10个/卵巢以下,无1例发生卵巢过度刺激综合征（OHSS）,6个月内16例妊娠;对照组患者的血清性激素水平无明显变化,卵巢基础窦卵泡计数仍为10个/卵巢以上,发生OHSS者1例,6个月内仅3例妊娠。结论常规治疗无效的PCOS不孕患者,经阴道行小卵泡穿刺抽吸为有效治疗途径。
Objective：To evaluate the effect of transvaginal immature follicle puncture to the antral follicle count in the ovaries and the pregnancy rate of the polycystic ovary syndrome（PCOS） associated infertility.Methods：80 patients with PCOS which underwent ovulation induction with HMG were randomly divided into observation group and control group.Each group had 40 cases.The observation group were performed transvaginal immature follicle puncture when follicular diameters were 8 to 10 mm;The control group were given routine ovulation induction and were observed 6 months consecutively,the change of serum FSH,LH and T level were observed before and after the treatment.the antral follicle counts in the ovaries and pregnancy rate were compared between two groups.Results：The ratio of serum LH：FSH and T level had decreased in 21 cases and became normal in 5 cases in the observation group There were significant difference in ratio of serum LH：FSH and T level（P0.01）after this operation There was no difference in control group.The antral follicle counts decreased to less than 10 per single ovary in 40 cases in observation group,No OHSS was observed.Sixteen of them were pregnant within 6 months.There was no marked change in hormone level in the control group,and the antral follicle count was still more than 10 per single ovary.One patient had OHSS,and only three patients were pregnant.Conclusion：Transvaginal immature follicle puncture is an effective way for those patients with PCOS which failed with conventional therapy.
出处
《中国优生与遗传杂志》
2011年第8期116-118,共3页
Chinese Journal of Birth Health & Heredity
