新生儿血清促甲状腺激素受体抗体水平探讨

Approach on neonatal serum thyrotrophin receptor antibody level

目的探讨新生儿血清促甲状腺激素受体抗体(TRAb)含量与母体TRAb含量相关性以及TRAb对新生儿甲状腺功能的影响。方法采用放射免疫法(RIA)测定286例新生儿甲状腺功能及血清TRAb含量,以观察新生儿甲状腺功能状况。结果非甲状腺疾病不同患儿TRAb含量无显著性差异,新生儿与母体TRAb含量具有相关性,新生儿甲状腺疾病与他类疾病比较有显著性差异。结论曾患甲状腺疾病的或疑似病例母体,母子均应查TRAb,及时发现母体甲状腺激素异常及对新生儿甲状腺功能的影响,避免影响儿童生长发育。

Objective It is to approach the correlation of neonatal and maternal serum levels of thyrotrophin receptor antibody（TRAb） and the influence of maternal serum levels of TRAb on neonatal thyroid function.Methods The thyroid functions and serum TRAb contents in 286 cases of neonate were determined with radioimmunoassay（RIA）,which was used to observe the situation of neonatal thyroid function.Results The TRAb contents in different children without thyroid diseases had no significant difference.The TRAb contents in neonate had correlation with that in puerpera.Neonatal thyroid disease had significant difference with others diseases.Conclusion Puerpera and neonate,who suffer suspected cases of thyroid disease,should check TRAb.Timely detection of anomalies maternal thyroid hormone and the influence on neonatal thyroid function can avoid affecting the growth and development of children.