清瘀化浊汤对代谢综合征大鼠血清C反应蛋白、肿瘤坏死因子-α及白细胞介素-6表达的影响

Influence of Qingyuhuazhuo decoction on expression of serum C reactive protein,tumor necrosis factor-α and interleukin-6 in metabolic syndrome rats

目的观察清瘀化浊汤对代谢综合征(MS)大鼠的治疗效果及对血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)表达的影响。方法采用高糖高脂高盐饲料喂养,制造MS大鼠模型。30只MS大鼠随机分为3组:模型组、西药对照组和中药治疗组,治疗8周后观察各组大鼠体质量、血糖、血脂、血压及血清CRP、TNF-α和IL-6表达的变化。结果西药对照组和中药治疗组大鼠体质量、血糖、总胆固醇和血压较模型组均显著下降(P均<0.05),其中体质量和血压中药治疗组下降程度均高于西药对照组(P均<0.05),中药治疗组对血脂的调节程度明显好于西药对照组(P<0.05)。2个治疗组血清CRP、TNF-α及IL-6表达量较模型组均有显著下降(P均<0.05),中药治疗组IL-6下降程度高于西药对照组(P<0.05)。结论具有化痰活血作用的清瘀化浊汤对防治MS有良好的疗效。

Objective It is to observe the treatment effectiveness of Qingyuhuazhuo decoction on metabolic syndrome（MS） rats and the influence on the expressions of serum C reactive protein（CRP）,tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6）.Methods MS rat model was established with high-glucose,high-fat and high-salt diet.Thirty MS rats were randomly divided into model group,western medicine（WM） control group and traditional Chinese medicine（TCM） treatment group.The changes of body mass,blood glucose,blood lipid,blood pressure（BP） and the expressions of serum CRP,TNF-α and IL-6 in all the groups were observed after 8 weeks of treatment.Results The levels of body mass,blood glucose,total cholesterol and BP in WM control group and TCM treatment group were significant lower than those in model group（all P0.05）.Among them,the lowering degrees of body mass and BP in TCM treatment group were higher than those in WM control group（both P0.05）.The regulating degree of blood lipid in TCM treatment group was better than that in WM control group（P0.05）.The expressions of serum CRP,TNF-α and IL-6 in the two treatment groups were significant lower than those in model group（all P0.05）.The lowering degree of IL-6 in TCM treatment group were higher than that in WM control group（P0.05）.Conclusion Qingyuhuazhuo decoction,which has the role of dissipating phlegm and activating blood circulation,has better treatment effectiveness on MS.