脐带间充质干细胞经肝动脉灌注治疗失代偿期肝硬化患者

The efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with decompensated cirrhosis after hepatitis B

目的观察人脐带间充质干细胞治疗失代偿期肝硬化患者的有效性。方法失代偿期乙型肝炎肝硬化患者10例,经肝动脉灌注人脐带间充质干细胞2×107个。比较患者在移植前及移植后1、4、8、12、24周肝功能以及临床病情的变化情况。结果随访过程中,患者乏力、尿少、水肿症状在第1~2周即明显缓解,食欲较术前明显增加,腹水消退快,腹胀明显减轻,2~6个月症状持续缓解,合并肝性脑病患者意识障碍频率明显减少,大部分患者术后意识障碍逐渐减轻到基本缓解,期间患者未进一步补充白蛋白、血浆、抗昏迷等治疗。结论人脐带间充质干细胞移植治疗失代偿期肝硬化短期疗效较好,长期疗效有待进一步观察。

Objective To observe the safety and efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with decompensated cirrhosis after hepatitis B.Methods Ten patients were included in the study.All patients were administered 2×107 human umbilical cord mesenchymal stem cells（hUC-MSCs） via intrahepatic arterial infusion.Changes of symptoms and liver function at 1,4,8,12,24 weeks were evaluated.Results During the follow-up,symptoms such as weak,oliguresis,abdominal distention and edema released within 2 weeks.Appetite increased and abdominal distention improved significantly within 2-6 weeks.The frequency of conscious disturbance in patients complicated with hepatic encephalopathy decreased.Most of patients have released conscious disturbance during the treatment.All the patients have no history of supplementing albumin,blood plasma and have no need for treating coma.Conclusion hUC-MSCs for decompensated cirrhosis patients is effective and its long-term efficacy is needed to study.