脂肪肝与高尿酸血症关系的探讨

The relationship between fatty liver and hyperuricemia

目的探讨脂肪肝与高尿酸血症的关系。方法 119例脂肪肝患者分成非高尿酸血症组和高尿酸血症组,分析两组的人口学特征及生化指标,将21例非酒精性脂肪性肝病患者分成高尿酸血症组和非高尿酸血症组,分析两组的肝组织学特征,采用二分类Logistic逐步回归分析评价脂肪肝患者发生高尿酸血症的危险因素。结果男性脂肪肝患者的尿酸高于女性脂肪肝患者,差异有统计学意义,脂肪肝高尿酸血症组与非高尿酸血症组的甘油三酯、总胆固醇、载脂蛋白B差异有统计学意义,非酒精性脂肪性肝病患者高尿酸血症组的脂肪变性程度较非高尿酸血症组重,炎症和纤维化程度两者差异无统计学意义,二分类Logistic逐步回归分析显示,饮酒、性别、高胆固醇血症是脂肪肝发生高尿酸的危险因素。结论脂肪肝与高尿酸血症关系密切,高尿酸血症会加重非酒精性脂肪性肝病患者的肝细胞脂肪变性,脂肪肝发生高尿酸血症的危险因素包括饮酒、男性和高胆固醇血症。

Objective To explore the relationship between fatty liver and hyperuricemia.Methods One hundred and ninteen patients with fatty liver were divided into non-hyperuricemia and hyperuricemia group.The demographic characteristics and biochemical parameters were analyzed.Twenty-one patients with non-alcoholic fatty liver disease were also divided into non-hyperuricemia and hyperuricemia groups and the liver histology was analysed.Logistic tests were used to evaluate risk factors of hyperuricemia in fatty liver patients.Results Uric acid of male patients with fatty liver was higher than that of female patients（P0.05）.There were significant differences between the two groups in the levela of triglycerides,total cholesterol,apolipoprotein B（P0.05）.The severity of steatosis of non-alcoholic fatty liver disease was more significant in groups with hyperuricemia than non-hyperuricemia.Inflammation and fibrosis between the two groups were no statistical difference.Logistic tests indicated that alcohol drinker,male and hyperholesterolemia were risk factors of hyperuricacid.Conclusion Fatty liver correlated positively to hyperuricacid.Steatosis in patients with non-alcoholc fatty liver disease would be aggregated by hyperuricemia.Alcohol coasumption,male and hypercholesterolemia were risk factors of hyperuricemia for fatty liver.