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线粒体功能不全与非酒精性脂肪性肝病 被引量：1

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摘要 非酒精性脂肪性肝病（NAFLD）是遗传、环境、代谢、应激相关因素所致的一种慢性肝脏疾病,包括单纯性脂肪肝、脂肪性肝炎和脂肪性肝硬化三种类型。NAFLD的发病机制复杂,
作者 曹伟 赵彩彦
机构地区 河北医科大学第三医院感染科
出处 《肝脏》 2011年第3期256-259,共4页 Chinese Hepatology
关键词 非酒精性脂肪性肝病 功能不全 线粒体 慢性肝脏疾病 单纯性脂肪肝 脂肪性肝硬化 脂肪性肝炎 NAFLD
分类号 R575.5 [医药卫生—消化系统]
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参考文献21

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  • 2Patti ME, Butte AJ, Crunkhorn S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A, 2003,100 : 8466-8471.
  • 3Pessayre D, Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol, 2007,22 : S20-S27.
  • 4Bach D, Naon D, Pich S, et al. Expression of Mfn2, the Charcot- Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes,obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes, 2005, 54:2685-2693.
  • 5Soriano FX, Liesa M, Bach D, et al. Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-aetivated receptor gamma coactivator-lalpha, estrogen-related receptoralpha ,and mitofusin 2. Diabetes,2006,55: 1783-1791.
  • 6Anello M, Lupi R, Spampinato D, et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia, 2005,48 : 282-289.
  • 7Lameloise N, Muzzin P, Prentki M, et al. Uncoupling protein 2:a possible link between fatty acid excess and impaired glucoseinduced insulin secretion? Diabetes, 2001,50:803-809.
  • 8Krauss S, Zhang CY, Scorrano L, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest,2003,112: 1831-1842.
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肝脏
2011年 第3期

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