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后适应对缺血性脑损伤神经保护的策略及分子机制 被引量：2

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摘要 后适应是一种新的内源性的神经保护策略可能通过调控再灌注血流而减轻缺血性脑损伤,其保护效应取决于循环次数、每次循环时间、实施时间和脑缺血模型。后适应的保护机制可能与其调节早期再灌注及与蛋白激酶Akt、细胞外信号调节激酶(ERK1/2)、蛋白激酶C(PKC)、ATP敏感性钾通道(KATP)、核转录因子-кB(NF-κB)和低氧诱导因子-1(HIF-1)参与的信号转导途径有关。
作者 谭慧敏 李燕 朱榆红
机构地区 昆明医学院第二附属医院神经内科
出处 《国际神经病学神经外科学杂志》 2011年第3期269-273,共5页 Journal of International Neurology and Neurosurgery
基金 云南省科技厅-昆明医学院联合基金(2008CD018)
关键词 缺血 脑 后适应 信号转导 神经保护
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献19

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同被引文献55

  • 1杜景卫,夏作理.小胶质细胞与缺血性脑损伤[J].中国临床康复,2005,9(25):168-169. 被引量：4
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国际神经病学神经外科学杂志
2011年 第3期

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