均匀设计优选智能型密闭敷料支架基质配方

Optimization of the matrix formulation of enclosed dressing intelligent scaffolds by uniform design

背景:近年来创伤敷料的研究发展较快,但很少有中药联合高分子材料制备的复合密闭敷料,且现有的创伤敷料作用较局限,不能适用于任何创伤伤口,但怎样使高分子材料与中药完美的融合是目前一个热门的话题。目的:优选智能型密闭敷料支架的最佳基质配方。方法:采用均匀设计法结合SPSS16.0软件进行多元线性回归分析,对敷料支架的吸水性、含水量、保湿性和外观评价等指标进行综合考察,优化智能型密闭敷料支架的基质设计。结果与结论:通过实验数据分析,优选出智能型密闭敷料支架最佳基质配方比例为:壳聚糖:明胶:甘油:聚乙烯醇:聚乙二醇=8.3:4.4:3.1:3.7:1。提示智能型密闭敷料支架基质处方配比合理、制作工艺质量可控。

BACKGROUND：In recent years,the wound dressing research has developed quickly,but few reports addressing the closed dressings prepared by traditional Chinese medicine combined with polymer composite,the efficacy of existing wound dressings is limited and not suitable for all wounds.But how to make polymer materials and traditional Chinese medicine to mix perfectly is a hot topic recently.OBJECTIVE：To optimize the matrix formulation of enclosed dressing intelligent scaffolds.METHODS：Multiple regression analysis with uniform design and SPSS 16.0 software was used to optimize the matrix formulation of enclosed dressing intelligent scaffolds and survey the aspects comprehensively,such as water absorption of dressing scaffolds,moisture content,relative moisture retention,hand evaluation indicators and so on.RESULTS AND CONCLUSION：The optimum dressing scaffolds matrix formulation ratio was as follows：chitosan：gelatin：glycerol：polyvinyl alcohol：polyethylene glycol = 8.3：4.4：3.1：3.7：1,according to analysis of experimental data.It is indicated that the prescription ratio of the matrix formulation of enclosed dressing intelligent scaffolds is feasible.In addition,the technique of the enclosed dressing intelligent scaffolds is steerable.