聚对苯二甲酸乙二醇酯表面接枝改性及其血液相容性的研究进展

Research progress of surface grafting polymerization and blood compatibility of polyethylene terephthalate

背景:聚对苯二甲酸乙二醇酯是一种具有优良的力学性能、化学惰性的聚酯材料,但由于聚合材料的血液相容性不高,因此需对其表面进行修饰,改善其血液相容性。目的:结合凝血机制简要介绍聚对苯二甲酸乙二醇酯材料表面接枝改性方法及其改性后的血液相容性。方法:检索1990/2009PubMed、SDOS及CNKI数据库有关凝血发生机制、抗凝血药物的种类和其对凝血发生的影响以及聚对苯二甲酸乙二醇酯材料本体性质、材料表面接枝的方法及其血液相容性评价等方面的文献。结果与结论:目前聚对苯二甲酸乙二醇酯表面接枝改性的方法局限性在于表面接枝的分子只能改变材料某种特性,而生物材料在人体内所处环境极为复杂,通过单一的改变材料某些性质很难使材料血液相容性得到根本性的改善。因此从仿生学角度通过接枝特殊分子诱导具有生理活性的血管内皮细胞黏附和生长,构建一种类似于天然血管壁模式的材料表面势必成为未来提高生物材料血液相容性的重要方向。

BACKGROUND：Polyethylene terephthalate is a kind of polyester materials with excellent mechanical properties and chemical inertia,but the surface must be modified and their blood compatibility should be improved because of poor blood compatibility of polymeric materials.OBJECTIVE：Based on clotting mechanism,this study introduced surface grafting modification method of polyethylene terephthalate and the blood compatibility after the modification.METHODS：A computer-based online search of PubMed,SDOS and CNKI database from 1990 to 2009 was performed for articles about the mechanism of blood coagulation,type of anticoagulant drugs and their effects on blood coagulation,as well as the polyethylene terephthalate properties,surface grafting method and blood compatibility evaluation.RESULTS AND CONCLUSION：The molecules grafted on the surface just modify a sort of specific properties of materials,which is the limitation of the current approaches of surface grafting polymerization of polyethylene terephthalate.Yet the environment where biomaterials exist in vivo is extremely complex,it is hard to fundamentally improve the blood compatibility of materials through modifying specific properties of materials solely.Then,through inducing the vascular endothelial cell that has physiological activity to adhere and grow by grafting specific molecules from the point of view of bionics,a novel surface which is similar to the model of natural vessel wall can be constructed that will must become the next major direction of promoting the blood compatibility of biomaterials.