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美金刚口服液治疗中重度阿尔茨海默病的疗效及安全性 被引量：4

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摘要 目的评价美金刚口服液治疗中重度阿尔茨海默病(AD)的疗效和安全性。方法符合《精神疾病诊断和统计手册》第四版(DSM-Ⅳ)AD诊断标准的48例患者进行美金刚口服液和美金刚片的随机、双盲、双模拟的对照研究,美金刚口服液组24例,美金刚片组24例,治疗16 w。阿尔茨海默病评定量表认知次级量表(ADAS-Cog)、日常生活能力量表(ADL)、临床疗效总评量表(CGI)评估临床疗效,实验室检查和临床观察评定不良反应。结果经16 w治疗,两组ADAS-cog、ADL、CGI评分治疗前后比较差异有显著性(P<0.01),两组间比较差异无显著性(P>0.05)。两组间不良反应的发生率无显著性差异(P>0.05),常见乏力等。结论美金刚口服液治疗中重度AD疗效好,不良反应少而轻,适合临床应用。
作者 白燕 姜红燕 许秀峰
机构地区 昆明医学院第一附属医院精神科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第14期2654-2656,共3页 Chinese Journal of Gerontology
基金 烟台荣昌制药有限公司资助 北京德众万全阳光医药科技有限公司协助
关键词 阿尔茨海默病 美金刚片 美金刚口服液 双盲对照研究
分类号 R749 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献13

  • 1Bakchine S,Loft H. Memantine treatment in patients with miht to moderate Alzheimer's disease: results of a randomised, double-blind, placebocontrolled 6-month study[J]. J Alzheimers Dis ,2008 ; 13 ( 1 ) :97-107.
  • 2Johnson JW, Kotermanski SE. Mechanism of action of memantinc [J]. Current Opin Pharmaco ,2006 ;6( 1 ) :61-7.
  • 3Schmitt HP. On the paradox of ion channel blockade and its benefits in the treatment of Alzheimer disease [J]. Med Hypotheses, 2005 ; 65 ( 2 ) : 2594-5.
  • 4Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate to severe Alzheimer's disease[J]. N Engl J Med,2003 ;348(14) :1333-41.
  • 5Reisberg B, Doody R, Stoffier A, et al. A 24 week open label extension study of memm~tine in moderate to severe Alzheimer disease [J].Arch Neuro1,2006 ;63 ( 1 ) :49-54.
  • 6Bullock R. Efficacy and safety of memantine in moderate to severe Alzhei- mer disease:the evidence to date[J]. Alzheimer Dis Assoc Disord ,2006; 20( 1 ) :23-9.
  • 7Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil : a randomized controlled trial [J]. JAMA,2004 ;291 ( 3 ) : 317-24.
  • 8Rustembegovica A,Soficb E,Sapeaninb A. A placebo-controlled study of memantine in dementia of Wernicke-Korsakoff syndrome, Alzheimer' s disease and in vascular dementia[J]. J Neurol Sci, 2009 ; 240 ( 320 ) : 283.
  • 9Sonkusare SK, Kaui CL, Ramarao P. Dementias of Alzheimer's disease and other necurodegenerative disorders memantine, a new hope [J]. Pharmacol Res ,2005 ;51 ( 1 ) : 12-7.
  • 10Plosker CL, Lyseng-Wilijamson KA. Memantine: a pharmacoeconomic review of its use in moderate to severe Alzheimer's disease [J]. Pharmacoeeonomies ,2005 ;23 ( 2 ) : 193-206.

二级参考文献9

  • 1Parsons CG,Danysz W,Quack G.Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data.Neuropharmacology,1999,38:735-767.
  • 2American psychiatric assosition.Diagnostic and statistical manual of mental disorders.4th ed.Washington:American Psychiatric Press,1994.147-154.
  • 3McKhann G,Drachman D,Folstein M,et al.Clinical diagnosis of Alzheimer's disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.Neurology,1984,34:939-944.
  • 4Blessed G,Tomlinson BE,Roth M.Blessed-Roth Dementia Scale (DS).Psychopharmacol Bull,1988,24:705-708.
  • 5Cacabelos R,Takeda M,Winblad B.The glutamatergic system and neurodegeneration in dementia:preventive strategies in Alzheimer's disease.Int J Geriatr Psychiatry,1999,14:3-47.
  • 6Tariot PN,Farlow MR,Grossberg GT,et al.Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil:a randomized controlled trial.JAMA,2004,291:317-324.
  • 7Reisberg B,Doody R,Stoffler A,et al.Memantine in moderate-to-severe Alzheimer's disease.N Engl J Med,2003,348:1333-1341.
  • 8Winblad B,Poritis N.Memantine in severe dementia:results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).Int J Geriatr Psychiatry,1999,14:135-146.
  • 9张振馨,洪霞,李辉,赵洁皓,黄觉斌,魏镜,王建明,李舜伟,杨恩立,吴继星,冀成君,王新德.北京城乡55岁或以上居民简易智能状态检查测试结果的分布特征[J].中华神经科杂志,1999,32(3):149-153. 被引量：147

共引文献28

同被引文献30

  • 1李格,沈漁邨,陈昌惠,李淑然,赵友文,刘棉,许亮,王兰香,王勤.老年痴呆简易测试方法研究——MMSE 在城市老年居民中的测试[J].中国心理卫生杂志,1988,2(1):13-18. 被引量：137
  • 2陈霞,张振馨,王新德,姚景莉,陈生弟,钱采韻,肖世富,舒良,汤洪川.美金刚在阿尔茨海默病患者中的疗效与耐受性多中心研究[J].中华神经科杂志,2007,40(6):364-368. 被引量：18
  • 3彭丹涛,许贤豪.轻度认知损害向老年性痴呆转化的临床研究[J].中华神经科杂志,2007,40(6):418-421. 被引量：15
  • 4Cummings JL. Cole G. Alzheimer disease [ J ]. JAMA, 2002,287 ( 17 ) :2335-2338.
  • 5Dodart JC, Marr RA, Koistinaho M,et al. Gene delivery of human apolipoprotein E alters brain AI3 burden in a mouse model of Alzheimer' s disease [ J ]. PNAS, 2005, 102(4) :1211-1216.
  • 6Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis [ J ]. Science,2003,300 ( 5618 ) :486-489.
  • 7Johnson JW, Kotermanski SE. Mechanism of action of memantine [ J ]. Curr Opin Pharmacol, 2006,6 ( 1 ) : 61- 67.
  • 8Lipton SA. Paradigm shift in neuropmtection by NMDA receptor blockade : memanfine and beyond [ J ]. Nat Bey Drug Discov ,2006 ,5 ( 2 ) : 160-170.
  • 9Schmitt Hp. On the paradox of ion channel blockade and its benefits in the treatment of Alzheimer disease [ J ]. Med Hypotheses,2005,65 ( 2 ) :259-265.
  • 10Riordan KC, Hoffman Snyder CR, Wellik KE, et al. Effectiveness of adding rnemantine to an Alzheimer dementia treatment regimen which already includes stable donepezil therapy: a critically appraised topic [ J ]. Neurologist ,2011,17 ( 2 ) : 121-123.

引证文献4

二级引证文献11

中国老年学杂志
2011年 第14期

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