凌蔻导浊排毒方对大鼠实验性胃溃疡的影响

Effect of Lingkou daozhuo paidu prescription on experiment gastric ulcer rat

目的探讨凌蔻导浊排毒方对动物实验性胃溃疡的作用及机制。方法 40只大鼠随机分成空白组、模型组、治疗组、对照组,每组10只,除空白组外,其余各组采用冰醋酸腐蚀法造模。造模后空白、模型两组给生理盐水,治疗组予凌蔻导浊排毒方,对照组给奥美拉唑,均通过灌胃途径给药。观察溃疡指数,测定大鼠血清NO含量及血管内皮生长因子(VEGF)。结果治疗组与对照组相比,能明显降低大鼠的溃疡指数(P<0.05),提高血管内皮生长因子(VEGF)的表达(P<0.05),升高大鼠血清NO含量(P<0.05)。结论凌蔻导浊排毒方对胃溃疡具有较好促愈合作用,其作用机制可能与促进胃黏膜保护因子NO的合成和释放以及明显升高VEGF的水平有关。

Objective To discusses the effect of Lingkou daozhuo paidu prescription on experimental gastric ulcer rat and its mechanism.Methods 40 rats were randomly divided into blank,model,treatment and control groups（n=10）.Except rats in blank group,rats models in other groups were made by glacial acetic acid etching.Rats were given normal saline in blank and model groups,Lingkou daozhuo paidu prescription in treatment group and omeprazole in control group.Ulcer index,NO content in serum and VEGF were detected.Results Compare with control group,the ulcer index was decreased,VEGF and NO were increased in treatment group（P〈0.05）.Conclusions Lingkou daozhuo paidu prescription can promote healing of gastric ulcer,which mechanism may be connected with promoting NO synthesis and releasing and increasing VEGF level.