不透X线标记物法在评价结肠传输功能中的作用

Role of Radioopaque Markers Method in the Evaluation of Colonic Transit Function

背景:功能性便秘(FC)常以结肠运动功能障碍为主要表现,结肠传输时间(CTT)是反映结肠运动功能的重要指标。目的:探讨不透X线标记物法在评价结肠传输功能以及诊断FC中的作用。方法:采用不透X线标记物法测定32名健康对照者的全结肠传输时间(TCCT)、右半结肠传输时间(RCTT)、左半结肠传输时间(LCTT)和直肠乙状结肠传输时间(RSCTT),同时检测26例FC患者和32名健康对照者不同时间点钡条排出率。结果:健康对照者TCTT、RCTT、LCTT和RSCTT分别为(20.31±11.00)h、(4.43±4.58)h、(8.44±4.01)h和(7.48±7.89)h,男女之间相比差异无统计学意义(P>0.05)。FC组不同时间点钡条排出率均显著低于健康对照组(P<0.01)。以72 h标记物残留率>20%为标准,26例FC患者中有19例可判断为结肠传输减慢。结论:不透X线标记物法简单易行、易于广泛开展,可准确有效地评价结肠传输功能,并在FC病因诊断中起有重要作用。

The major manifestation of functional constipation （FC） is often described as the disturbance of colonic function, and colonic transit time （CCT） is the main indicator which can reflect the function of colonic motility. Aims： To investigate the role of radioopaque markers method in evaluating the colonic transit function and the diagnosis of FC. Methods： The radioopaque markers method was used to evaluate total colonic transit time （TCCT）, right colonic transit time （RCTF）, left colonic transit time （LCTT） and rectosigmoid colonic transit time （RSCTT） in 32 healthy subjects, and the excretion rates of barium strips at different time points were measured in 26 FC patients and 32 healthy subjects. Results： TCTF, RCTT, LCTT and RSCqT in healthy subjects were （20.31±11.00） hours, （4.43±4.58） hours, （8.44±4.01） hours and （7.48±7.89） hours, respectively. No statistical differences of TCCT, RCTF, LCTF and RSCTY were found significantly between male and female healthy subjects （P〉0.05）. Excretion rates of barium strips at different time points in FC patients were significantly lower than those in healthy subjects （P〈0.01）. If the cutoff value was set at 72-hour residual rate 〉20%, of the 26 FC patients there were 19 patients showing a slow colonic transit time. Conclusions： The radioopaque markers method is a simple method which can be easily performed, and can evaluate the colonic transit function in an accurate and effective way. Further more, it may play an important role in the diagnosis of FC.