大麻素系统与胃肠道内脏痛调控关系的研究进展

Progress in Study on Relationship between Cannabinoids and Regulation of Visceral Pain of Gastrointestinal Tract

腹痛是功能性胃肠病(FGIDs),特别是肠易激综合征(IBS)的主要症状之一,严重影响患者的生活质量。然而,其病理生理学机制复杂且仍未明确。大麻素已被应用于疼痛机制的研究和临床治疗,但成瘾性等中枢系统不良反应限制了其应用。因此,研究大麻素系统的外周作用途径,对提高大麻素治疗慢性疼痛(特别是内脏痛)的效果,具有重要意义。本文就大麻素系统与胃肠道内脏痛调控关系的研究进展作一综述。

Abdominal pain is one of the main symptoms of functional gastrointestinal disorders （FGIDs）, especially the irritable bowel syndrome （IBS）, which severely affects the life quality of patients. However, its pathophysiologie mechanism is complicated and has not been clarified. Cannabinoids has been applied in studies on the mechanism of pain and in clinical treatment, but addiction and other central nervous system side effects have restricted its application. Therefore, the study on peripheral action of cannabinoids is of great significance in raising the efficacy of cannabinoids on curing chronic pain （especially visceral pain）. This article reviewed the progress in investigating on the relationship between cannabinoids and regulation of visceral pain of gastrointestinal tract.