重症肌无力危象的多因素分析(附252例报告)

Multivariate analysis of risk factors for myasthenic crisis—a 252 cases analysis study

目的探讨重症肌无力危象发生的危险因素。方法回顾性分析2000年1月至2011年2月间我院收治的252例II型重症肌无力患者的临床资料,选性别、发病年龄、病程、激素治疗、免疫抑制剂的应用、合并感染、胸腺切除术史、伴随自身免疫病等因素,进行多因素回归分析,分析其对重症肌无力危象发生的影响。结果共发生危象108例,危象的发生与合并感染、胸腺切除术史、发病年龄及激素的使用有关。结论合并感染、胸腺切除术史、发病年龄及激素的使用是重症肌无力危象发生的危险因素,认识这些危险因素对于预防危象的发生,改善预后提供了依据。

Objective To explore the risk factors of myasthenie crisis in myasthenia gravis （MG） patients. Methods A retrospective study was conducted in 252 MG patients from January 2000 to February 2011. The following factors were evaluated ： sex, age of onset, course of disease, eortieosteroid treatment, use of immunosuppressant, combined infection, thymectomy and concomitant autoimmune diseases. Multivariate logistic regression analysis was used to find the risk factors of myasthenic crisis. Results One hundred eight patients developed myasthenie crisis during this study. The results of statistie showed that age of onset, eortieosteroid treatment, combined infection and thymectmny were associated with the development of myasthenic crisis. Conclusions age of onset, eorticosteroid treatment, combined infection and thymectomy are the risk factors of myasthenic crisis. Managing those risk factors would be helpful for prevention of myasthenic crisis and improvement of its prognosis.