1Darnel1 JE Jr. Transcription factors as targets for cancer therapy [J]. Nat Rev Cancer, 2002, 2(10) : 740 -749.
2Lin Q, Lai R, Chirieae LR. Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells [J]. Am J Pathol, 2005, 167(4) : 969 -980.
3Haura EB. SRC and STAT pathways[J]. J Thorac Oncol, 2006, 1 (5) : 403 - 405.
4Sen B, Saigal B, Parikh N, et al. Sustained Sre inhibition results in signal transducer and activator of transcription 3 ( STAT3 ) activation and cancer cell survival via altered Janus-activated kinase- STAT3 binding[J]. Cancer Res, 2009, 69(5) : 1958 -1965.
5Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STA33 [ J ]. Nature Reviews Cancer, 2009, 9 ( 11 ) : 798 - 809.
6Atkinson GP, Nozell SE, Benveniste ET. NF-kappaB and STAT3 signaling in glioma : targets for future therapies [J]. Expert Rev Neurother, 2010, 10(4): 575-586.
7Lee H, Herrmann A, Deng JH, et al. Persistently activated STAT3 maintains constitutive NF-kB activity in tumors [ J ]. Cancer Cell, 2009, 15(4) : 283 -293.
8Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets [ J ]. Prec Natl Acad Sci USA, 2006, 103(7) : 2257 -2261.
9Thales P, Alice Sh, Kenneth SK. MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells [ J]. Cancer Research, 2008, 68 (19) : 8164 - 8172.
10Iliopoulos D, Jaeger SA, Hirsch HA, et al. STAT3 activation of miR -21 and miR - 181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer [ J ]. Mol Cell, 2010, 39(4) : 493 -506.
4Yang ZZ,Tschopp O,Di-Po(i) N,et al.Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKB gamma on thymus,skin,and cardiovascular and nervous system development in mice[J].Mol cell Biol,2005,25(23):10407-10418.
5Engelman JA,Luo J,Cantley LC.The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism[J].Nat Rev Genet,2006,7(8):606-619.
6Cantley LC,Neel BG.New insights into tumor suppression:PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway[J].Proc Natl Acad Sci USA,1999,96(8):4240-4245.
7Koul D,Parthasarathy R,Shen R,et al.Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN[J].Oncogene,2001,20(46):6669-6678.
8Takeda A,Osaki M,Adachi K,Jones DR.Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines[J].Pancreas,2004,28(3):353-358.
9Denlinger CE,Rundall BK,Jones DK.Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo[J].J Thorac Cardiovasc Surg,2005,30(5):1422-1429.
10Maier D,Jones G,Li X,et al.The PTEN lipid phosphatase domain is not required to inhibit Invasion of glioma cells[J].Cancer Res,1999,59(21):5479-5482.