四川北部地区肺癌患者GSTT1基因多态性分析

Genetic polymorphism of GSTT1 to lung cancer patients in north Sichuan

目的:了解四川北部地区汉族肺癌人群GSTT1基因多态性状况,与其他地区人群人种进行比较。方法:采用聚合酶链式反应(PCR)技术检测该地区肺癌患者GSTT1基因缺失〔GSTT1(-)〕频率。结果:本地区肺癌患者GSTT1(-)频率为45%(45/100),其中纯和缺失率女性和男性分别为52.0%(13/25)和42.7%(32/75),χ2=0.660,P=0.417;鳞癌38.1%(16/42),腺癌48.0%(12/25),χ2=0.632,P=0.427;吸烟者44.4%(28/63),不吸烟者45.9%(17/37),χ2=0.021,P=0.884。结论:本地区肺癌患者GSTT1基因缺失频率高于欧美,与亚洲多中心研究结果类似,缺失频率与性别、病理类型及是否吸烟无关。

OBJECTIVE：To analysis the genetic polymorphism of GSTT1 to lung cancer patients in North Sichuan of China and compared with race from other districts.METHODS： The genotypes of GSTT1（GSTT1（-）） were detected with polymerase chain reaction technique in lung cancer patients of North Sichuan of China.RESULTS： In local lung cancer patients,the frequency of homozygous deletions（null genotype） for GSTT1 was 45%（45/100）.Among the patients,the frequencys of null genotype for GSTT1 were 52.0%（13/25） in female and 42.7%（32/75） in male（χ2=0.660,P=0.417）.It were 38.1%（16/42） in patients with squamous cell carcinoma and 48.0%（12/25） in patients with adenocarcinoma respectively（χ2=0.632,P=0.427）.And 44.4%（28/63） in smoleers,45.9%（17/37） in no smolcers,χ2=0.021,P=0.884.CONCLUSION： The frequency of deletions of GSTT1 in lung cancer patients from North Sichuan is higher than the results of Asiatic multicenter and exceeding those of Europe and America,and has nothing to do with gender,pathological type and smoking.