肝脏自然杀伤细胞在慢性肝病中的作用

Role of liver NK cells in chronic liver diseases

肝脏自然杀伤细胞(NK)是一种与外周血NK细胞不同的肝脏免疫细胞。近年来研究表明肝脏NK细胞在各种慢性肝脏疾病中起重要作用。包括对抑制病毒感染和肿瘤细胞生长,对抗肝纤维化均有益处,但同时其又刺激肝损伤和抑制肝再生(肝细胞增殖)。本文就肝脏NK细胞的特征、功能以及在各种常见慢性肝病中作用进展作一综述。

Liver natural killer cells （NK） cells are one type of hepatic immune cells derived from peripheral blood NK cells. Recent studies show that liver NK cells play an important role in various chronic liver diseases, including inhibition of viral infection and tumor cell growth and anti fibrosis. On the other hand, they also cause liver injury and inhibit liver regeneration. In this paper, the features and functions of liver NK cells and the recent progress of the role of liver NK cells in chronic liver disease are reviewed.