静脉水化疗法预防经皮冠状动脉介入术后造影剂肾病

Intravenous hydration therapy in prevention of contrast-induced nephropathy after percutaneous coronary intervention

目的:探讨静脉水化疗法预防经皮冠状动脉介入术(PCI)后造影剂肾病(CIN)的预防作用。方法:选择PCI患者180例,采用非随机分组观察,将观察对象分为强化饮水组(对照组)86例和静脉水化组(静脉组)94例,比较2组术前、术后血清肌酐(SCr)、尿素氮(BUN)、血β2微球蛋白(β2-mG)、尿β2-mG等结果。结果:静脉组术后SCr、BUN、β2-mG及尿β2-mG均明显低于对照组(P<0.01);静脉组术后发生CIN 3例,对照组术后CIN 10例,2组差异有统计学意义(P<0.05)。结论:与术后48 h不限制饮水的水化方法比较,通过静脉注射等渗氯化钠溶液进行水化可以预防肾功能损伤,并有效减少术后急性肾衰竭的发生。

Objective：To investigate the effect of intravenous hydration therapy in prevention of contrast-induced nephropathy（CIN） after percutaneous coronary intervention（PCI）.Methods：One hundred and eighty cases of patients were divided into the control group（drinking water） and experimental group（intravenous hydration therapy）.The levels of serum creatinine（SCr）,urea nitrogen（BUN）,serum β2-microglobulin（β2-mG）,and urinary β2-mG were compared between the two groups after PCI.Results：The levels of SCr,BUN,β2-mG,and urinary β2-mG were significantly lower in experimental group（n=94） than that in control group（n=86）（P0.01）;CIN occurred in 3 cases of experimental group,but 10 cases of control group（P0.05）.Conclusions：Intravenous hydration therapy can prevent the injury of kidney function and reduce the incidence of acute renal failure after PCI.