硫酸软骨素膜剂制备及对口腔粘膜损伤防治作用研究

Studies on the Membranous Preparation of Chondroitin Sulfate and Its Effect on Oral Mucous Membrane Damage

探讨制备硫酸软骨素膜剂的方法及其对大鼠口腔粘膜损伤的药理作用。方法：依据医院制剂规范要求，以ＰＶＡ为包衣材料制备性质均一、溶出度较好的硫酸软骨素膜剂剂型；利用大鼠口腔粘膜损伤模型，通过病理观察比较其对粘膜损伤的防治作用。结果：硫酸软骨素膜剂的平均含量为 ６． ０５ ｍｇ／片，重量差异与卫生度均符合规范要求，适于口腔、皮肤等组织粘膜给药。实验证明硫酸软骨素膜剂具有减轻大鼠口腔粘膜损伤程度，提前修复等作用。结论：硫酸软骨素可制成一种新型粘膜保护剂型，并具有一定的粘膜保护作用。

Purpose: The aim was to study the method for preparing CS membranous preparation and its pharmacological effect on damaged oral mucous membrane. Methods: According to the stipulations of clinical preparations, CS membrane was prepared with PVA, glycerol, tween 80 as materials. an ideal rat oral mucous membrane damaged model was established in refer to many other related models. Results: Each piece of membranous preparation contained 6mg CS. The use of CS membrane on the model showed that CS could promote the process of repairing injured mucous membrane and oral ulcer. Conclusion: The experiment showed that CS can become a cheap. nontoxic. nonirritant and effective drug in treating injured oral mucous membrane and other mucous membrane damages.