阴茎肉瘤样癌临床病理观察（附文献复习）

Sarcomatoid carcinoma of penis-a clinicopatholo.qical review

目的探讨阴茎肉瘤样癌的临床和病理学特点。方法对1例阴茎肉瘤样癌，通过临床表现、组织形态、免疫组化进行分析，并复习相关文献。结果镜下见肿瘤大部分区域为梭形细胞肉瘤样，呈席纹状排列，较多大的单核样细胞和少数巨细胞，核分裂易见，少部分高分化鳞状细胞癌区域。免疫组化检测梭形肉瘤样区域vimentin阳性，p63、CK14和PCK散在阳性，Ki67（40％），EMA阴性。鳞状细胞癌形态区域：PCK、CK14阳性，vimentin和p63散在阳性，EMA阳性，Ki67（60％）。p53、P16、S-100、desmin、action阴性。结论阴茎肉瘤样癌是阴茎恶性肿瘤中的一种罕见类型，具有高度侵袭性，易在局部反复复发并早期发生淋巴结转移。

Objective To investigate the clinical and pathological features of penile sarcomatoid carcinoma. Methods Clinical characteristics, histomorphology and immunohistochemistry of one case of penile sarcomatoid carcinoma were analyzed, and the related studies on this disease were reviewed. Results The histological analysis showed that a high-grade squamous cell carcinoma with associated undifferentiated spindle cell differentiation. Immunohistochemistry staining demonstrated the epithelial component PCK（ ＋ ）, CK 14（ ＋ ）, Vimentm（＋ ）, t）63（＋ ）, EMA（＋ ）, Ki67 （60% X＋ ）, and the spindle cell component Vimentin（＋）, PCK/CK14/p63 patch（＋） and EMA（-）. Conclusion Sarcomatoid carcinoma of penis is a rare malignant tumor with high invasion potential. It frequently reoccur and spread lymph node.