摘要
烯二炔类抗生素因强的抗肿瘤活性而受到重视。近年报道与单抗偶联的烯二炔类抗生素有力达霉素(Lidamycin,LDM)、新制癌菌素(Neocarzinostatin,NCS)和卡利奇霉素(Calicheamicins,CLM)。本文突出阐明了其靶向药物的研究进展,同时也介绍了其辅基蛋白、新型筛选模型、产生菌发酵方面的最新动态。
Abstract： Enediyne antibiotics are attractive to many researchers because of the strong antitumor-activity. Many enediyne antibiotics which coupled with antibodies, such as lidamycin, neocarzinostatin and calicheamicins, were discussed in recent reports. Recent progresses on the targeted drugs of enediyne products were highlighted. Apoprotein, new screening model and fermentation of enediyne antibiotics were also introduced
出处
《国外医药（抗生素分册）》
CAS
2011年第4期150-155,共6页
World Notes on Antibiotics
关键词
烯二炔类抗生素
辅基蛋白
筛选模型
发酵
靶向药物
enediyne antibiotics
apoprotein
screening model
fermentation
targeted drugs
