摘要
以药物妥拉苏林为模板分子,在羧基修饰的介孔硅表面印迹聚合,制得对妥拉苏林有较好选择识别能力的分子印迹聚合物(molecularly imprinted polymer,MIP)。将所得的MIP制成碳糊电极传感器,用循环伏安法对传感器进行研究,结果表明,该MIP能选择性吸附妥拉苏林,在优化实验条件下,传感器的氧化峰峰值与妥拉苏林浓度在0.4～5μmol/L和5～100μmol/L的范围内呈良好的线性关系,相关系数分别为0.9717和0.9940,检测限为1.6×10-8mol/L。MIP用于人尿样的分析时,回收率为97.5%～104.2%,相对标准偏差为0.03%～0.21%,结果较为满意。
molecularly imprinted polymer（MIP） for selectively sensing tolazoline, which was synthesized using tolazoline as the template and carboxyl modified mesoporous silica （SBA-15） as the supporter. Based on that, carbon paste electrode was prepared and the sensor was tested by cyclic voltametry. The result showed the sensor displayed a good linear range of 0.4-5 μmol/L and 5 × 100 μmol/L under optimized conditions,R was 0.971 7 and 0.994 0 respectively and the detected limit was 1.6 × 104 mol/L. The MIP sensor was used for urine sample and the recovery was in the range of 97.5%- 104.2%. Additionally, the relative standard deviation （RSD） was from 0.03% to 0.21%.
出处
《化学传感器》
CAS
2011年第2期42-47,共6页
Chemical Sensors
基金
中央高校基本科研业务费专项资金(No.XDJK2009C091)资助项目
关键词
电化学传感器
循环伏安法
分子印迹聚合物
介孔硅
妥拉苏林
electrochemical sensor
, cyclic vohametry
molecularly imprinted polymer
mesoporous silica
tolazoline
