2,3-二-O-甲氧乙基-6-O-苄基-β-环糊精的合成及其气相色谱性能

Preparation of 2,3-Di-O-methoxyethyl-6-O-benzyl-β-cyclodextrin and Study on Its Gas Chromatographic Behavior

将β-环糊精的2,3位引入甲氧乙基,6位引入苄基,合成新的环糊精衍生物2,3-二-O-甲氧乙基-6-O-苄基-β-环糊精,并采用静态法涂渍5g·L^(-1)新环糊精制备石英毛细管色谱柱,考察了毛细管柱的柱性能和分离性能。结果表明:该固定相对Grob试剂、苯的二取代位置异构体二氯苯、硝基甲苯和溴甲苯以及手性化合物α-乙基-2-甲氧基苯甲醇、α-乙基-3-甲氧基苯甲醇、α-甲基-对氯苯乙腈、α-苄基-对氯苯乙腈、1-(2′,4′-二氯苯氧基)-2-丙醇和2-溴丙酸甲酯都具有良好的分离效果。

A new derivative of cyclodextrin namely 2,3-di-O-methoxyethyl-6-O-benzyl-β-eyclodextrin was synthesized by substituting the OH-group at 2 and 3 positions of theβ-cyclodextrin molecule by methoxyethyl groups,and OH-group at 6 position by benzyl group.This compound was used as a chiral stationary phase coated on the quartz capillary chromatographic column with total concentration of 5 g·L^（-1）.The column property and separation capacity of this capillary column were studied.It was found that excellent separation efficiency was obtained on this column for the following compounds：Grob test mixture,disubstituted benzene isomers（e.g., dichlorobenzene,nitrotoluene,bromotoluene,etc.） and several chiral compounds[e.g.,α-ethyl-2-methoxybenzyl alcohol,α-ethyl-3-methoxy benzyl alcohol,α-methyl-4-chlorobenzylcyanide,α-benzyl-4-chlorobenzyl cyanide,l-（2＇, 4＇-dichlorophenoxy）-2-propanol and methyl-2-bromopropionate].