摘要
将β-环糊精的2,3位引入甲氧乙基,6位引入苄基,合成新的环糊精衍生物2,3-二-O-甲氧乙基-6-O-苄基-β-环糊精,并采用静态法涂渍5g·L^(-1)新环糊精制备石英毛细管色谱柱,考察了毛细管柱的柱性能和分离性能。结果表明:该固定相对Grob试剂、苯的二取代位置异构体二氯苯、硝基甲苯和溴甲苯以及手性化合物α-乙基-2-甲氧基苯甲醇、α-乙基-3-甲氧基苯甲醇、α-甲基-对氯苯乙腈、α-苄基-对氯苯乙腈、1-(2′,4′-二氯苯氧基)-2-丙醇和2-溴丙酸甲酯都具有良好的分离效果。
A new derivative of cyclodextrin namely 2,3-di-O-methoxyethyl-6-O-benzyl-β-eyclodextrin was synthesized by substituting the OH-group at 2 and 3 positions of theβ-cyclodextrin molecule by methoxyethyl groups,and OH-group at 6 position by benzyl group.This compound was used as a chiral stationary phase coated on the quartz capillary chromatographic column with total concentration of 5 g·L^(-1).The column property and separation capacity of this capillary column were studied.It was found that excellent separation efficiency was obtained on this column for the following compounds:Grob test mixture,disubstituted benzene isomers(e.g., dichlorobenzene,nitrotoluene,bromotoluene,etc.) and several chiral compounds[e.g.,α-ethyl-2-methoxybenzyl alcohol,α-ethyl-3-methoxy benzyl alcohol,α-methyl-4-chlorobenzylcyanide,α-benzyl-4-chlorobenzyl cyanide,l-(2', 4'-dichlorophenoxy)-2-propanol and methyl-2-bromopropionate].
出处
《理化检验(化学分册)》
CAS
CSCD
北大核心
2011年第7期753-756,共4页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
关键词
气相色谱
Β-环糊精衍生物
石英毛细管色谱柱
手性固定相
GC
Derivative ofβ-cyclodextrin
Quartz capillary chromatographic column
Chiral stationary phase