部分功能性梅毒螺旋体蛋白的分子研究进展

Researoh progress in molecular biology of Treponema Pallium on some functional proteins

由于梅毒螺旋体不能在体外培养,抗原获取不易,因此梅毒的早期研究进展缓慢。梅毒螺旋体基因组测序完成后,得益于生物信息学技术,人们陆续发现了一系列与梅毒免疫应答、致病力和感染黏附相关的功能蛋白分子。这些蛋白的发现,使人们对梅毒的感染和免疫以及致病机制有了更深入的了解。本文从分子生物学水平介绍了与梅毒免疫应答、致病和黏附相关的功能性蛋白的研究情况。

Syphilis, a sexually transmitted infection caused by the spirochetal bacterium Treponema pallidum , remains a global concerned public health problem. Been studied for centuries, however, the progress on syphilis had been hindered by the inability to continuously culture this organism in vitro. 1 Thanks to the appliance of bioinformatics, people now have a deeper understanding on some functional proteins which may relating to immune response, virulence and adhesion during the infection phase of syphilis. This review summarized some functional proteins crucial to the infection process of Treponema pallidum at molecular level.