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Aglycin在小鼠组织中的定位 被引量：1

The distribution of Aglycin in mice tissues
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摘要 在研究胃肠道生物活性肽时,从猪小肠中分离鉴定了一个蛋白aglycin.初步的研究表明,aglycin对糖代谢具有调节作用,为了进一步探讨aglycin在体内生理功能,本研究采用western blot和免疫组织化学的手段检测其在SD小鼠机体不同组织中的分布情况.结果显示在小肠、肌肉和脑组织中存在aglycin阳性免疫反应. This paper isolates and characterizes a novel bioactive polypeptide with regulatory function ofglycometabolism from porcine intestine called aglycin. The present study investigates the distribution of aglycin in several SD mice tissues. The results indicate that there is positive immunological reaction of aglycin in intestine, muscle and brain.
作者 赵燕英 陈正望 王建和
机构地区 西南民族大学生命科学与技术学院 华中科技大学生命科学与技术学院
出处 《西南民族大学学报（自然科学版）》 CAS 2011年第4期582-585,共4页 Journal of Southwest Minzu University(Natural Science Edition)
基金 国家"863"高技术研究发展计划(2002AA214061) 国家自然科学基金项目(30370647 30470823)资助
关键词 aglycin 豌豆胰岛素 PA1b 组织定位 aglycin leginsulin PAIb distribution
分类号 Q5 [生物学—生物化学]
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参考文献10

  • 1DUN XP, WANG JH, CHEN L, et al. Activity of the plant peptide aglycin in mammalian systems [J]. FEBS Journal, 2007(274): 751-759.
  • 2陈磊,赵燕英,顿新鹏,陈正望,陆婕.植物多肽激素PA1b的纯化鉴定及功能研究[J].华中农业大学学报,2006,25(6):586-590. 被引量：6
  • 3WATANABE Y, BARBASHOV SF, KONATSU S, et al. A peptide that stimulates phosphorylation of the plant insulin-binding protein: Isolation, primary structure and cDNA cloning [J]. Eur J Biochem, 1994(224): 167-172.
  • 4HIGGINS TJ, CHANDLER PM, RANDALL PJ, et al. Gene structure, protein structure, and regulation of the synthesis of a sulfur-rich protein in pea seeds[J]. Biol Chem J, 1986, 261(24): 11124-11130.
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二级参考文献11

  • 1RYAN C A,PEARCE G,SCHEER J,et al.Polypeptide hormones[J].The Plant Cell,2002,14:251-264.
  • 2HIGGINS T J,CHANDLER P M,RANDALL P J,et al.Gene structure,protein structure,and regulation of the synthesis of a sulfur-rich protein in pea seeds[J].Biol Chem J,1986,261(24):11124-11130.
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  • 7CRAIK D J,DALY N L,WAINE C.The cystine knot motif in toxins and implications for drug design[J].Toxicon,2001,39:43-60.
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  • 9DERUA R,GUSTAFSON K R,PANNELL L K.Analysis of the disulfide linkage pattern in circulin A and B,HIV-inhibitory macrocyclic peptides[J].Biochem Biophysic Research Communications,1996,228:632-638.
  • 10JOUVENSAL L,LOUIS S,QUILLIEN L,et al.PA1b,an insecticidal protein extracted from pea seeds (Pisum sativum):1H-2D-NMR study and molecular modeling[J].Biochemistry,2003,42:11915-11923.

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西南民族大学学报（自然科学版）
2011年 第4期

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