建立“人工面神经技术”恢复周围性面瘫兔的闭眼功能

Establishing "Artificial Facial Nerve" to Recover Eye-closed Function of Rabbit Model with Peripheral Facial Paralysis

目的:建立"人工面神经技术"以恢复单侧周围性面瘫兔的眼轮匝肌闭眼功能,为周围性面瘫提供一种新的治疗手段。方法:制备单侧周围性面瘫兔,建立健侧眼轮匝肌肌电信号采集、中枢信号处理模式识别、患侧电流刺激眼轮匝肌系统。当健侧眼轮匝肌采集的肌电信号经信号识别、提取以及电脑分析判断,符合其闭眼刺激阈值时,即对人工电刺激器发出指令,由刺激电极直接作用于患侧眼轮匝肌,引起眼睑完全闭合结果:以最小电流刺激患侧眼轮匝肌,引起眼睑完全闭合刺激方式为正负矩形波,电流强度为0.30～0.50mA。结论:利用可植入式微机电技术,在单侧周围性面瘫模型建立"人工面神经反射弧",恢复患侧眼轮匝肌闭眼收缩,可维持双侧闭眼功能的对称性和同步性。

Objective： To establish ＂artificial facial nerve＂ to recover eye-closed fimction of rabbit model with half peripheral facial paralysis. Methods： The rabbit model was prepared with half peripheral facial paralysis. The electromyographic （EMG） signal collection, center signal procession, electric current excitation was constructed When EMG signal gathered by gather electrodes was larger than the stimulus threshold of eye-closed, artificial electrical stimulator send out orders to excite directly to musculus orbicularis oculi （OOM） so as to closeeyelid. Results： Electrical current with smallest intensity （0.30-0.50mA, positive- negative square wave） to stimulate paralyzed OOM to close eyelid. Conclusion： Constructing ＂artificial facial nerve reflex＂ on half peripheral facial paralysis of rabbit model with micro electronic mechanical system （MEMS） technique can help OOM to contract synchronism and symmetry.