希明婷片对卵巢功能低下所致骨质疏松症的疗效观察

Clinical observation of ximingtingpian in treatment of osteoporosis result in hypofunction of ovary

目的观察希明婷片治疗卵巢功能低下所致骨质疏松症的临床疗效。方法将60例卵巢功能低下所致骨质疏松症患者按随机数字表法分为试验组（口服希明婷片治疗）和对照组（口服激素替代治疗），每组30例。分别于治疗前及治疗后6个月检测骨密度、骨钙素、雌二醇、卵泡刺激素（FSH）、子宫内膜厚度、血常规、尿常规、肝功能、肾功能。结果试验组和对照组治疗后骨密度、骨钙素[骨密度：（0．606±0．059）、（0．617±0．065）g／cm^2；骨钙素：（8．87±5．54）、（8．92±4．43）g/L]均较治疗前[骨密度：（0．537±0．068）、（0．552±0．073）g／cm^2；骨钙素：（6．78±3．97）、（6．83±4．29）g/L]提高（P〈0．05）；试验组治疗前后雌二醇、FSH比较差异无统计学意义（P〉0．05），对照组治疗前后比较差异有统计学意义（P〈0．01）。试验组疗效、主要症状总有效率分别为93．3％（28／30）、93．3％（28／30），对照组分别为90．0％（27／30）、86．7％（26／30），两组比较差异均无统计学意义（P〉0．05）。两组治疗前后血常规、尿常规、肝功能、肾功能比较差异均无统计学意义（P〉0．05）。结论希明婷片对卵巢功能低下所致骨质疏松症的治疗效果明显并且安全。

Objective To observe the clinical effects of ximingting pian in treatment of osteoporosis result in hypofunction of ovary. Methods Sixty women with osteoporosis result in hypofunction of ovary were divided into two groups by random digits table with 30 cases each. The investigated group received ximingting pian, the controlled group received hormone replacement therapy （HRT）. The changes of bone density, bone gla protein（BGP）, estradiol, follicle-stimulating hormone（ FSH ）, the thickness of endometrium, blood routine,urine routine,liver function and kidney function before and after 6 months treatment were measured. Results Bone density and BGP after treatment was higher than that before treatment in two groups [in investigated group：（0.606 ± 0.059） g/cm^2 vs. （0.537 ±0.068） g/cm^2 and （8.87 ± 5.54） g/L vs. （6.78 ±3.97 ） g/L; in controlled group ： （0.617 ±0.065 ） g/cm^2 vs. （0.552 ±0.073 ） g/cm^2 and （8.92 ±4.43 ） g/L vs. （6.83 ±4.29 ） g/L ] （P 〈 0.05 ）. The levels of estradiol and FSH had no marked changes in investigated group （P 〉 0.05 ）;but not this in controlled group （P 〈 0.01 ）. The total effective rate of curative effect and presenting symptom was 93.3% （28/30）, 93.3% （28/30） in investigated group and 90.0% （27/30）, 86.7% （26/30） in controlled group, there was no significant difference between two groups （P 〉 0.05 ）. There was no significant difference in blood routine,urine routine,liver function and kidney function before and after treatment in two groups （P 〉 0.05 ）. Conclusion Ximingting pian is efficacious and safe in the treatment of osteoporosis result in hypofunction of ovary.