山慈菇外敷治疗骨转移癌疼痛的临床观察

Clinical Observation on Metastatic Bone Pain Treated with Application Therapy with Pseudobulbus Cremastrae Seu Pleiones

目的评价山慈菇配合三阶梯止痛和单纯三阶梯止痛治疗骨转移癌疼痛的有效性。方法观察山慈菇粉外敷联合盐酸羟考酮控释片(奥施康定)治疗肿瘤骨转移癌疼痛的临床疗效。通过对有中、重度疼痛的41名肿瘤骨转移患者随机分组,连续观察14 d,采用χ2检验,对两组疼痛缓解情况、盐酸羟考酮控释片(奥施康定)用药剂量、体力状况评分情况进行观察和分析。结果治疗后治疗组疼痛缓解情况明显优于对照组(P<0.05);治疗组奥施康定使用量增加率远低于对照组(P<0.05);两组治疗后体力状况评分提高率比较,治疗组高于对照组(P<0.05)。结论山慈菇粉外敷对治疗骨转移癌疼痛有明显提高止痛作用的效果,减少强阿片类药物奥施康定的使用剂量,对提高患者生存质量有重要意义。

Objective To assess the effectiveness on metastatic bone pain treated with the combined therapy of pseudobulbus cremastrae seu pleiones and three-step analgesic ladder or with simple three-step analgesic ladder.Methods The clinical efficacy was observed on metastatic bone pain treated with the combined therapy of application with pseudobulbus cremastrae seu pleiones and oxycodone hydrochloride（oxycontin）.41 cases of bone metastasis with moderate and serious pain were divided into two groups randomly,and were observed continuously for 14 days.χ2 test was adopted to observe and analyze pain relieving situation,dose of oxycodone hydrochloride（oxycontin）and physical state score.Results After treatment,the situation of pain relieving in treatment group was obviously superior to that in control group（P0.05）.In treatment group,the dose increasing rate of oxycontin was lower than that in control group（P0.05）.The improvement of physical state score in treatment group was better than that in control group after treatment（P0.05）.Conclusion The application with pseudobulbus cremastrae seu pleiones can obviously improve the analgesic effect in treatment of metastatic bone pain and reduce the dose of opiate,oxycontin.It plays the significant role in the improvement of survival quality of patients.