蛭丹消脂汤治疗气滞血瘀、痰湿内阻型冠心病60例疗效观察

Efficacy Observation of Zhidan Xiaozhi Decoction in 60 Cases of Coronary Heart Disease of Qi and Blood Stagnation Pattern and Internal Retention of Phlegm Damp Pattern

目的观察蛭丹消脂汤治疗冠心病(气滞血瘀、痰湿内阻型)的临床疗效及其对血浆超敏C反应蛋白(hsCRP)、内皮素(ET)、血脂等的影响。方法将120例患者随机分为对照组和治疗组两组,每组60例。对照组采用西医常规治疗;治疗组在对照组治疗基础上加服蛭丹消脂汤。两组疗程均为4周,分别测定两组治疗前后的hsCRP、ET、血脂,并观察临床症状改善情况。结果治疗组临床症状改善的显效率、总有效率分别为63.3%、93.10%,对照组分别为40.0%、63.33%,两组比较,差异有统计学意义(P<0.01)。治疗后治疗组hsCRP、ET均明显降低,与本组治疗前比较,差异有统计学意义(P<0.01);且治疗组hsCRP、血脂改善与对照组比较,差异有统计学意义(P<0.05)。结论蛭丹消脂汤治疗气滞血瘀、痰湿内阻型冠心病,不仅能改善其临床症状,并能显著降低hsCRP、ET,改善血脂的异常。

Objective To observe the clinical efficacy of zhidan xiaozhi decoction on coronary heart disease(qi and blood stagnation pattern and internal retention of phlegm damp pattern)as well as its impacts on high sensitivity C reactive protein(hsCRP),endothelin(ET),blood lipid,etc.Methods 120 cases were divided randomly into a treatment group and a control group,60 cases in each one.In control group,the conventional treatment with western medicine was applied.In treatment group,on the basis of the treatment as control group,zhidan xiaozhi decoction was supplemented.The cases in either group were treated for 4 weeks.Before and after treatment,the levels of hsCRP,ET and blood lipid were detected in two groups separately and the improvements in clinical symptoms were observed.Results In treatment group,the remarkably effective rate of the improvements in clinical symptoms were 63.3% and the total effective rate was 93.10%.In control group,they were 40.0% and 63.33% separately.The statistical significant differences presented in comparison of two groups(P<0.01).After treatment,the levels of hsCRP and ET reduced apparently in treatment group,which was statistically and significantly different as compared with those before treatment(P<0.01).Additionally,the improvements in hsCRP and blood lipid after treatment in treatment group were different significantly in statistics as compared with those in control group(P<0.05).Conclusion In treatment of coronary heart disease of qi and blood stagnation pattern and internal retention of phlegm damp pattern,zhidan xiaozhi decoction not only relieves clinical symptoms,but also significantly reduces the levels of hsCRP and ET and improves in the abnormality of blood lipid.