摘要
目的:考察羟丙基-β-环糊精包合对细辛脑脑靶向生物利用度的影响。方法:以家兔鼻腔分别灌流细辛脑羟丙基-β-环糊精溶液剂与细辛脑水饱和溶液剂进行比较,考察羟丙基-β-环糊精包合细辛脑后药物的生物利用度。结果:羟丙基-β-环糊精溶液家兔鼻腔灌流后,家兔血液、嗅脑、大脑、筛鼻甲部位的吸收量均高于水饱和溶液,具有统计学意义。结论:细辛脑与羟丙基-β-环糊精形成包合物,经兔鼻腔灌流后,家兔血液、嗅脑、筛鼻甲、大脑吸收量均高于水饱和溶液,细辛脑的生物利用度得到提高。
Objective：To observe the bioavailability of α-asarone by its inclusion complex of hydroxypropylcyclodextrins.Method：Rabbits were divided into two groups according to different solvents.The bioavailability of α-asarone was compared between the inclusion complex of hydroxypropylcyclodextrins group and water solution group in blood drug concentration,the content of ethmoidal concha,cerebral and olfactory brain.Result：The content of α-asarone in blood,olfactory brain,ethmoidal concha and cerebral has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.Conclusion：α-asarone has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第15期21-23,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省中医药管理局课题(2008198)
关键词
细辛脑
生物利用度
环糊精
α-asarone
bioavailability
hydroxypropylcyclodextrins
