摘要
目的:探讨中药有效成分配伍对脑缺血损伤大鼠脑组织内神经生长因子(NGF)水平改变的影响。方法:将SD大鼠随机分为假手术组、模型组、川+葛(川芎嗪50 mg.kg-1+葛根素50 mg.kg-1)组、尼莫地平(0.5 mg.kg-1)组,采用改良的Pulsinelli四血管法制备脑缺血损伤动物模型,于再灌注0时、6时分组ip 1次。再灌注24 h后用免疫组织化学法测定NGF的水平。结果:模型组脑组织NGF含量较假手术组减少;川+葛组较模型组NGF含量增高,神经功能测定也有一定的提高。结论:川芎嗪与葛根素配伍对脑缺血损伤有一定改善作用,其作用机制可能与提高NGF含量有关。
Objective：To determine the effects of combined treatment of ligustrazine with puerarin on nerve growth factor（NGF） level in rats with cerebral ischemia injury. Method： Rats were randomized into sham-operation group, model group, ligustrazine-puerarin group（50 mg-kg-lfor both） and nimodipine group（0.5 mg.kg^-1）. The four vessel occlusion method was used to establish the model. The level changes of NGF in brain and the changes of nerve function were investigated. Result： Compared with sham-operated group, in model group rats, the level of NGF in brain was decreased significantly; compared with model group the neuronal damage and reactions improved injury to were alleviated after the treatment, the content of NGF in brain was increased, and nerve Conclusion： The combined treatment of ligustrazine with puerarin can prevent and cure some degrees inflammatory function was the ischemia
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第15期218-220,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
陕西省科技厅自然基金项目(20105Q4024)
